Scott Soderling

Scott H. Soderling, Ph.D. (University of Washington)

Chair of Cell Biology
George Barth Geller Distinguished Professor for Research in Molecular Biology
Professor of Cell Biology
Professor of Neurobiology

Director of the Transgenic Mouse Facility


318 Nanaline Duke Building, Box 3709
Duke University Medical Center
Durham, NC 27710

Telephone (919) 684-9001
Fax (919) 684-5481

Lab Site

The capacity of the brain to organize sensory input into precise movements, thoughts, emotions, and memories is the culmination of thousands of protein complexes organized spatially within neurons and astrocytes to control neural connectivity, activity, and plasticity.  Human genetics is discovering large numbers of candidate genes whose disruptions lead to critical perturbations in protein function underling disorders such as Autism, Intellectual Disability, and Schizophrenia.  How these proteins function and how they are organized into neural sub-compartments with the cellular landscape of the brain is unknown, hindering our ability to understand normal and maladaptive brain mechanisms.  Our laboratory is unlocking the molecular composition of key neural cell structures to discover how proteins implicated in brain disorders function to govern diverse cellular properties underlying behavior. To accomplish this we are utilizing novel proteomic, genome engineering, and neural circuit approaches that we have developed to functionally link how perturbations to neural proteomes alter brain function relevant to neurodevelopment and psychiatric disorders.  For current information about the lab please visit our Lab Website.

Recent Publications:

Erata E, Gao Y, Purkey AM, Soderblom EJ, McNamara JO, Soderling SH. Cnksr2 Loss in Mice Leads to Increased Neural Activity and Behavioral Phenotypes of Epilepsy-Aphasia Syndrome. JNeurosci. 2021 November 17. -PDF-

O’Neil SD, Racz B, Brown WE, Gao Y, Soderblom EJ, Yasuda R, Soderling SH. Action Potential-coupled Rho GTPase Signaling Drives Presynaptic Plasticity. eLife. 2021 July 16. -PDF-

Courtland JL, Bradshaw TW, Waitt G, Soderblom EJ, Ho T, Rajab A, Vancini R, Kim IH, Soderling SH. Genetic Disruption of WASHC4 Drives ends-lysomal Dysfunction and Cognitive-Movement Impairments in Mice and Humans. eLife. 2021 March 22. -PDF-

Black JB, McCutcheon SR, Dube S, Barrera A, Klann TS, Rice GA, Adkar SS, Soderling SH, Reddy TE, Gersbach CA . Master Regulators and Cofactors of Human Neuronal Cell Fate Specification Identified by CRISPR Gene Activation. Cell Reports. 2020 Dec 1. -PDF-

Takano T, Wallace JT, Baldwin KT, Purkey AM, Uezu A, Courtland JL, Soderblom EJ, Shimogori T, Maness PF, Eroglu C, Soderling SH. Chemico-genetic Discovery of Astrocytic Control of Inhibition In Vivo. Nature. 2020 Nov 11. -PDF-

Kim IH, Kim N, Kim S, Toda K, Catavero CM, Courtland JL, Yin HH, Soderling SH. Dysregulation of the Synaptic Cytoskeleton in the PFC Drives Neural Circuit Pathology, Leading to Social Dysfunction. Cell Reports. 2020 July 28. -PDF-

Uezu A, Hisey E, Kobayashi Y, Gao Y, Bradshaw TW, Devlin P, Rodriguiz R, Tata PR, Soderling SH. Essential Role for InSyn1 in Dystroglycan Complex Integrity and Cognitive Behaviors in Mice. Elife. 2019 Dec 12. -PDF-

Gao Y, Hisey E, Bradshaw TWA, Erata E, Brown WE, Courtland JL, Uezu A, Xiang Y, Diao Y, Soderling SH. Plug-and-Play Protein Modification Using Homology-independent Universal Genome Engineering. Neuron. 2019 Aug 21. -PDF-

Spence EF, Dube S, Uezu A, Locke M, Soderblom EJ, Soderling SH. In Vivo Proximity Proteomics of Nascent Synapses Reveals a Novel Regulator of Cytoskeleton-Mediated Synaptic Maturation. Nature Communications. 2019 Jan 23. -PDF-

Spence EF, Kanak DJ, Carlson BR, Soderling SH. The Arp2/3 Complex is Essential for Distinct Stages of Spine Synapse Maturation, Including Synapse Unsilencing. J Neuroci. 2016 Sept. 14. -PDF-

Uezu A, Kanak DJ, Bradshaw TWA, Soderblom EJ, Catavero CM, Burette AC, Weinberg RJ,  Soderling SH.  Identification of an Elaborate Complex Mediating Postsynaptic Inhibition. Science. 2016. Sept 9. -Full Text Link-  -Reprint Link-

Rossi MA, Li He, Lu D, Kim IH, Bartholomew RA, Gaidis E, Barter JW, Kim N, Cai MT, Soderling SH, Yin HH.  A GABAergic Nigrotectal Pathway for Coordination of Drinking Behavior. Nature Neuroscience. 2016. Apr 4. -PDF-

Singh SK, Stogsdill JA, Pulimood NS, Dingsdale H, Kim YH, Pilaz LJ, Kim IH, Manhaes AC, Rodrigues WS Jr, Pamukcu A, Enustun E, Ertuz Z, Scheiffele P, Soderling SH, Silver DL, Ji RR, Medina AE, Eroglu C. Astrocytes Assemble Thalmocortical Synapses by Bridging NRX1a and NL1 via Hevin. Cell. 2016 Jan 14. -PDF-

Spence EF, Soderling SH. Actin Out: Regulation of the Synaptic Cytoskeleton. J Biol Chem. 2015 Nov 27. -PDF-

Zuchero JB, Fu MM, Sloan SA, Ibrahim A, Olson A, Zaremba A, Dugas JC, Wienbar S, Caprariello AV, Kantor C, Leonoudakus D, Lariosa-Willingham K, Gertz K, Soderling SH, Miller RH, Barres BA. CNS Myelin Wrapping Is Driven by Actin Disassembly. Developmental Cell. 2015 Jul 27. -PDF-

Kim IH, Rossi MA, Aryal DK, Racz B, Kim N, Uezu A, Wang F, Wetsel W, Weinberg W, Soderling SH. Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine. Nature Neuroscience. 2015 May 4. -PDF- See highlights from the press: LA Times & Neuroscience News!

Risher WC, Patel S, Kim IH, Uezu A, Bhagat S, Wilton DK, Pilaz LJ, Sing Alvarado J, Calhan OY, Silver DL, Stevens B, Calakos N, Soderling SH, Eroglu C. Astrocytes refine cortical connectivity at dendritic spines. eLife. 2014 Dec 17:e04047. -PDF-

Soderling SH and Van Aelst L. Principles driving the spatial organization of Rho GTPase signaling at synapses. Ras Superfamily Small G Proteins: Biology and Mechanisms. 2014. Springer, pp 395-419. -PDF-

Kim IH, Wang H, Soderling SH, Yasuda R. Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall. eLife. 2014 Jul 8:e02839. -PDF-

Hazai D, Szudoczki R, Ding J, Soderling SH, Weinberg RJ, Sotonyi P, Racz B. Ultrastructural abnormalities in CA1 hippocampus caused by deletion of the actin regulator WAVE-1. PLoS One. 2013;8(9):e75248. -PDF-

Zhou K, Muroyama A, Underwood J, Leylek R, Ray S, Soderling SH, Lechler T. Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. Proc Natl Acad Sci U S A. 2013 Sept 16.  -PDF-

Kim IH, Racz B, Wang H, Burianek L, Weinberg R, Yasuda R, Wetsel WC, Soderling SH. Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities. J Neurosci. 2013 Apr 3;33(14):6081-6092.  -PDF-

Burianek LE, Soderling SH. Under lock and key: Spatiotemporal regulation of WASP family proteins coordinates separate dynamic cellular processes. Semin Cell Dev Biol. 2013 Jan 3. pii: S1084-9521(12)00229-7. -PDF-

Uezu A, Okada H, Murakoshi H, Del Vescovo CD, Yasuda R, Diviani D, Soderling SH. Modified SH2 domain to phototrap and identify phosphotyrosine proteins from subcellular sites within cells. Proc Natl Acad Sci U S A. 2012 Oct 1. -PDF-

Kim IH, Carlson BR, Heindel CC, Kim H, Soderling SH. Disruption of wave associated Rac-GAP (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus. J Biol Chem. 2012 Sep 24. -PDF-

Okada H, Uezu A, Soderblom EJ, Moseley MA 3rd, Gertler FB, Soderling SH. Peptide array X-linking (PAX): a new peptide-protein identification approach. PLoS One. 2012;7(5):e37035. Epub 2012 May 14. -PDF-

Okada, H., Uezu, A., Mason, F.M., Soderblom, E.J., Moseley III, M.A., Soderling, S.H. (2011) SH3 domain-based phototrapping in living cells reveals Rho family GAP signaling complexes. Sci Signal, 4(201):rs13. -PDF-

Mason, F.M., Heimsath, E.G., Higgs, H.N., and Soderling, S.H. (2011) Bi-modal regulation of a formin by srGAP2. J Biol Chem, 286(8):6577-6586. -PDF-

Carlson, B.R., Lloyd, K.E., Kruszewski, A., Rodriguiz, R.M., Faytell, M., Wetsel, W.C., and Soderling, S.H.  (2011) WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory.  J Neurosci, 31(7):2447-2460.  -PDF-

Svitkin, T., Lin, W.H., Webb, D.J., Yasuda, R., Wayman, G.A., Van Aelst, L., and Soderling, S.H. (2010) Regulation of the postsynaptic cytoskeleton: roles in development, plasticity, and disorders. J. Neuroscience, Nov. 10:14937-42.  -PDF-

Carlson, B. and Soderling, S.H. (2009). Mechanisms of cellular protrusions branch out. Dev Cell, 17(3):307-309. -PDF-

Click here for a full list of Publications.