Chantell Evans, PhD, assistant professor of cell biology, has been named a 2025 McKnight Scholar Award recipient in recognition of her pioneering research into the molecular mechanisms of neuronal mitophagy — a process critical to maintaining neuronal health. She is one of 10 scholars to receive this honor this year.
Neurodegenerative diseases such as Parkinson’s, Alzheimer’s, and ALS are marked by the progressive loss of neurons, but the underlying causes remain poorly understood. Evans’ research seeks to illuminate how neurons manage mitochondrial quality control, particularly through the mitophagy pathway, which removes damaged mitochondria. Her lab uses advanced live-cell imaging and other cutting-edge tools to explore how mitophagy is regulated in response to neuronal activity and how its disruption may contribute to disease onset.
By uncovering the spatial and temporal dynamics of mitophagy, Evans aims to identify novel mechanisms that could slow or halt the progression of neurodegenerative diseases, offering hope for future therapeutic breakthroughs.
The McKnight Scholar Awards, established in 1977, support exceptional early-career neuroscientists who are establishing independent research programs. The annual awards recognize scientists committed to solving significant problems in neuroscience and fostering inclusive, equitable lab environments. Evans’ selection reflects both her scientific excellence and her dedication to mentoring the next generation of neuroscientists.
The scholars receive three years of support, for a total award of $225,000, as well as the chance to join a community of the nation’s best neuroscientists.
“Receiving the McKnight Scholar Award is truly an honor. In challenging times, it will provide valuable funding and resources to continue our research into neurodegenerative diseases,” Evans said. “By joining the McKnight Scholars, I am excited to gain access to an elite community of leading neuroscientists where I will be able to share ideas and foster new collaborations. Finally, this award affirms my commitment to mentorship, inclusivity, and scientific excellence.”