Molecular Genetics of Development & Birth Defects Faculty

The development of complex organs from a single fertilized cell is a complicated series of genetic, signaling, and cellular events that must be tightly coordinated in time and space.  Our faculty are among the best in the world at discovering how these processes are regulated and occur.  To do this, they use an array of genetically tractable model organisms, including the fruit fly drosopholia, zebrafish, and mice.  Understanding how organisms develop has led to many new insights into how developmental defects in humans may also occur, including heart and lung defects, skin diseases, and Bardet-Biedl Syndrome to name a few.  See also the Duke Center for Human Disease Modeling associated with the Department, which is part of this effort.    Gifting and support for the important research conducted by faculty in this theme can be directed here.

Brigid L.M. Hogan, Professor and Chair

  Mammalian development and organogenesis; tissue stem cells

Michel Bagnat, Assistant Professor

  Cellular mechanisms of tube formation and fluid secretion in zebrafish

Blanche Capel, Professor

  Sex determination and mammalian development

Stefano Di Talia, Assistant Professor

  Quantitative systems level approach to Developmental Biology

Nicholas Katsanis, Professor

  Genetic and celluar basis of pleitropic disease

John Klingensmith, Associate Professor

  Molecular genetics of mammalian development and birth defects

Terry Lechler, Associate Professor

  Morphogenesis of epithelial tissues

Kenneth D. Poss, Professor

  Mechanisms of heart and fin regeneration in zebrafish, tissue regeneration and morphogenesis

Eda Yildirim, Assistant Professor

  Epigenetic regulation and nuclear organization in mammalian development and disease