Scott H. Soderling, Ph.D. (University of Washington)
Professor of Cell Biology
Professor of Neurobiology
Director of the Transgenic Mouse Facility
Director of Graduate Studies in Cell Biology
318 Nanaline Duke Building, Box 3709
Duke University Medical Center
Durham, NC 27710
Telephone (919) 684-9001
Fax (919) 684-5481
The capacity of the brain to organize sensory input into precise movements, thoughts, emotions, and memories is the culmination of thousands of protein complexes organized spatially within neurons and astrocytes to control neural connectivity, activity, and plasticity. Human genetics is discovering large numbers of candidate genes whose disruptions lead to critical perturbations in protein function underling disorders such as Autism, Intellectual Disability, and Schizophrenia. How these proteins function and how they are organized into neural sub-compartments with the cellular landscape of the brain is unknown, hindering our ability to understand normal and maladaptive brain mechanisms. Our laboratory is unlocking the molecular composition of key neural cell structures to discover how proteins implicated in brain disorders function to govern diverse cellular properties underlying behavior. To accomplish this we are utilizing novel proteomic, genome engineering, and neural circuit approaches that we have developed to functionally link how perturbations to neural proteomes alter brain function relevant to neurodevelopment and psychiatric disorders. For current information about the lab please visit our Lab Website.
Yan Z, Kim E, Datta D, Lewis DA, Soderling SH. (2016). Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders? J Neurosci. 36(45):11411-11417.
Spence EF, Kanak DJ, Carlson BR, Soderling SH. (2016). The Arp2/3 Complex Is Essential for Distinct Stages of Spine Synapse Maturation, Including Synapse Unsilencing. J Neurosci. 14;36(37):9696-709.
Uezu A, Kanak DJ, Bradshaw TW, Soderblom EJ, Catavero CM, Burette AC, Weinberg RJ, Soderling SH. (2016). Identification of an elaborate complex mediating postsynaptic inhibition. Science. 9;353(6304):1123-9.
Rossi MA, Li HE, Lu D, Kim IH, Bartholomew RA, Gaidis E, Barter JW, Kim N, Cai MT, Soderling SH, Yin HH (2016). A GABAergic nigrotectal pathway for coordination of drinking behavior. Nat Neurosci 19(5):742-8.
Singh SK, Stogsdill JA, Pulimood NS, Dingsdale H, Kim YH, Pilaz LJ, Kim IH, Manhaes AC, Rodrigues WS Jr., Pamukcu A, Enustun E, Ertuz Z, Scheiffle P, Soderling SH, Silver DL, Ji RR, Medina AE, Eroglu C (2016). Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin. Cell 164(1-2):183-96.
Spence EF, Soderling SH (2015). Actin Out: Regulation of the Synaptic Cytoskeleton. J Biol Chem. 290(48):28613-22.
Zuchero JB, Fu MM, Sloan SA, Ibrahim A, Olson A, Zaremba A, Dugas JC, Wienbar S, Caprariello AV, Kantor C, Leonoudakus D, Lariosa-Willingham K, Kronenberg G, Gertz K, Soderling SH, Miller RH, Barres BA. (2015). CNS Myelin Wrapping Is Driven by Actin Disassembly. Dev Cell. 34(2):152-67.
Kim IH, Rossi MA, Aryal DK, Racz B, Kim N, Uezu A, Wang F, Wetsel WC, Weinberg RJ, Yin H, Soderling SH. (2015). Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine. Nat Neurosci. 18(6):883-91.
Risher W.C., Patel S., Kim I.H., Uezu A., Bhagat S., Wilton D.K., Pilaz L.J., Singh Alvarado J., Calhan O.Y., Silver D.L., Stevens B., Calakos N., Soderling S.H., Eroglu C. (2014). Astrocytes refine cortical connectivity at dendritic spines. Elife 17;3.
Kim IH, Wang H, Soderling SH, Yasuda R. (2014). Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall. Elife. 8;3.