Marc G. Caron, Ph.D. (University of Miami)

James B. Duke Professor,
Department of Cell Biology
Programs: CMB, Cancer Biology


Email: marc.caron@duke.edu

487 CARL Building, Box 3287
Duke University Medical Center
Durham, NC 27710

Telephone
919-684-5433 (office)
919-684-6606/6094 (lab)
Fax 919-681-8641

Dopamine, serotonin, and norepinephrine are key neurotransmitters in the central nervous system that regulates behavior and mobility. Studies of the mechanisms of action and regulation of these and other neurotransmitters and hormones at the cellular and molecular levels constitute the main goals of our research activities. Our laboratory uses a wide variety of techniques including animal models, cell systems, and molecular approaches to investigate how G protein-coupled receptors (GPCR) and neurotransmitter transporters regulate homeostasis in health and diseases.

Recent Publications:

Jacobsen JP, Plenge P, Sachs BD, Pehrson AL, Cajina M, Du Y, Roberts W, Rudder ML, Dalvi P, Robinson TJ, O'Neill SP, Khoo KS, Morillo CS, Zhang X, Caron MG (2014) The interaction of escitalopram and R-cialopram at the human serotonin transporter investigate in the mouse. Pyschopharmacology (Epub ahead of print)

Daigle TL, Ferris MJ, Gainetdinov RR, Sotnikova TD, Urs NM, Jones SR, Caron MG (2014) Selective deletion of GRK2 alters psychostimulant-induced behaviors and Dopamine neurtransmission. Neuropsychopharmacology (Epub ahead of print)

Urs NM, Nicholls PJ, Caron MG (2014) Integrated approaches to understanding antipsychotic drug action at GPCRS. Curr Opin Cell Biol 27:56-62

Mariaon S, Urs NM, Peterson SM, Sotnikova TD, Beaulieu JM, Gainetdinov RR, Caron MG (2014) Dopamine D2 receptor relies upon PPM/PP2C protein phosphatases to dephosphorylate Huntingin protein. J Bol Chem 289(17):11715-24

Peddibhotla S, Hedrick MP, Hershberger P, Maloney PR, Li Y, Milewski M, Gosalia P, Gray W, Mehta A, Sugarman E, Hood B, Suyama E, Nguyen K, Heynen-Genel S, Vasile S, Salaniwal S, Stonich D, Su Y, Mangravita-Novo A, Vicchiarelli M, Roth GP, Smith LH, Chung TD, Hanson GR, Thomas JB, Caron MG, Barak LS, Pinkerton AB (2013) Discovery of ML314, a brain penetrant non-peptiditic β-Arrestin biased agaonist of the Neurotensis NTR1 receptor. ACS Med Chem Lett 4(9):846-851

Sachs BD, Ni JR, Caron MG (2014) Sex differences in response to chronic mild stress and congenital serotonin deficiency. Pyschoneuroendocrinology 40:123-9

Snyder JC, Rochelle LK, Barak LS, Caron MG (2013) The stem cell-expressed receptor Lgr5 possesses conanical and functionally active molecular determinants critical to β-arrestin-2 recruitment. PLoS one 8(12):e84476

Calipari ES, Ferris MJ, Salahpour A, Caron MG, Jones SR (2013) Mehylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression. Nat Commun 4:2720

Sachs BD, Salahi AA, Caron MG (2013) Congenital brain serotonin deficiency leads to reduce ethanol sensitivity and increased ethanol consumption in mice.  Neuropharmacology S0028-3908(13)00417-6

Burkhalter MD, Fralish GB, Premont RT, Caron MG, Phiipp M (2013) Grk5l Controls Heart Development by Limiting mTOR Signaling during Symmetry Breaking. Cell Rep 4(4):625:32

Sachs BD, Jacobsen JP, Thomas TL, Siesser WB, Roberts WL, Caron MG (2013) The effects of congenital brain serotonin deficiency on responses to chronic fluoxetine. Transl Psychiatry 3:e291

Philipp M, Evron T, Caron MG (2013) The role of arrestins in development.  Prog Mol Biol Transl Sci. 118:225-42

 

 

Click here for a full list of Publications.