Marc G. Caron, Ph.D. (University of Miami)

James B. Duke Professor of Cell Biology
Professor of Neurobiology
Professor - Track V in Medicine

Programs: CMB, Cancer Biology

Email: marc.caron@duke.edu

487 CARL Building, Box 3287
Duke University Medical Center
Durham, NC 27710

Telephone
919-684-5433 (office)
919-684-6606/6094 (lab)
Fax 919-681-8641

Dopamine, serotonin, and norepinephrine are key neurotransmitters in the central nervous system that regulates behavior and mobility. Studies of the mechanisms of action and regulation of these and other neurotransmitters and hormones at the cellular and molecular levels constitute the main goals of our research activities. Our laboratory uses a wide variety of techniques including animal models, cell systems, and molecular approaches to investigate how G protein-coupled receptors (GPCR) and neurotransmitter transporters regulate homeostasis in health and diseases.

 

Recent Publications:

Snyder JC, Rochelle LK, Ray C, Pack TF, Bock CB, Lubkov V, Lyerly HK, Waggoner AS, Barak LS, Caron MG. (2017). Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled Receptor-5 diminishes cell fitness. J Biol Chem. pii: jbc.M116.756635. [Epub ahead of print] 

Le Gonidec S, Chaves-Almagro C, Bai Y, Kang HJ, Smith A, Wanecq E, Huang XP, Prats H, Knibiehler B, Roth BL, Barak LS, Caron MG, Valet P, Audigier Y, Masri B. (2017). Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin. FASEB J. pii: fj.201601074R. [Epub ahead of print]

Zhu L, Almaça J, Dadi PK, Hong H, Sakamoto W, Rossi M, Lee RJ, Vierra NC, Lu H, Cui Y, McMillin SM, Perry NA, Gurevich VV, Lee A, Kuo B, Leapman RD, Matschinsky FM, Doliba NM, Urs NM, Caron MG, Jacobson DA, Caicedo A, Wess J. (2017).  β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions. Nat Commun. 2017 Feb 1;8:14295. 

Ray C, Soderblom EJ, Bai Y, Carroll FI, Caron MG, Barak LS. (2017). Probing the Allosteric Role of the α5 Subunit of α3β4α5 Nicotinic Acetylcholine Receptors by Functionally Selective Modulators and Ligands. ACS Chem Biol. doi: 10.1021/acschembio.6b01117. [Epub ahead of print] 

Urs NM, Peterson SM, Caron MG. (2017). New Concepts in Dopamine D(2) Receptor Biased Signaling and Implications for Schizophrenia Therapy. Biol Psychiatry. 1;81(1):78-85. doi: 10.1016/j.biopsych.2016.10.011. Review. PubMed PMID: 27832841.

Urs NM, Gee SM, Pack TF, McCorvy JD, Evron T, Snyder JC, Yang X, Rodriguiz RM, Borrelli E, Wetsel WC, Jin J, Roth BL, O'Donnell P, Caron MG. (2016). Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties. Proc Natl Acad Sci U S A. 13;113(50):E8178-E8186.

Jacobsen JP, Krystal AD, Krishnan KR, Caron MG. (2016). Adjunctive 5-Hydroxytryptophan Slow-Release for Treatment-Resistant Depression: Clinical and Preclinical Rationale. Trends Pharmacol Sci. 37(11):933-944. Review.

Barak LS, Bai Y, Peterson S, Evron T, Urs NM, Peddibhotla S, Hedrick MP, Hershberger P, Maloney PR, Chung TD, Rodriguiz RM, Wetsel WC, Thomas JB, Hanson GR, Pinkerton AB, Caron MG. (2016). ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse. ACS Chem Biol. 15;11(7):1880-90. 

Caron MG, Gether U. (2016). Structural biology: Antidepressants at work. Nature. 21;532(7599):320-1. 

Jacobsen JP, Rudder ML, Roberts W, Royer EL, Robinson TJ, Oh A, Spasojevic I, Sachs BD, Caron MG. (2016). SSRI Augmentation by 5-Hydroxytryptophan Slow Release: Mouse Pharmacodynamic Proof of Concept. Neuropsychopharmacology. 41(9):2324-34.

Click here for a full list of Publications.