Table 1. Cell
division proteins present and absent in bacterial genomes Ec Aac Hi Nm Vc Xf Yp Bs Bb Dr Hp Mtb Rp Sp Sy Tp Aa Tm Ct Mg Mpn Uu Af Ap Mj Mt Ph Pa ftsZ 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 0 2 0 2 1 1 3 ftsI 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 0 0 0 0 0 0 0 0 0 ftsA 1 1 1 1 1 1 1 1 1 1 1 0 1 1 0 1 1 2 0 0 0 0 0 0? 0 0 0 0 ftsQ* 1 1 1 1 1 1 1 div div? 0? 0 0 0 div 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ftsW 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1 1 1 0 0 0 0 0 0 0 0 0 ftsK* 1 1 1 2 1 1 1 3* 1 1 2 4-6 1 1 0 1 0 0 1 0 0 1? 0 0 0 0? 0 0 zipA 1 1 1 0 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 minC 1 1 0 1 1 1 1 1 0 0? 1? 0 0 0 1? 0 1? 1? 0 0 0 0 0? 0 0 0 0 0 minD* 1 1 0 2 1 1 1 2 1 1 2 0? 0 0 1 3 2 1 0 0 0 0 2 0 2 1 3 3 minE 1 1 0 1 1 1 1 0 0 1? 1 0 0? 0 1 0 0 0? 0 0 0 0 0 0 0 0 0 0 sulA 1 0 0 0? 0? 1 0 0 0 0 0 0 0 0? 0 0 0 0 0 0 0 0 0 0 0 0 0 SMC* muk muk muk 1 muk 1 muk 1 1 1 0 1 0 1 1 1 1 1 0 1 1 0 1 0 1 0 1 1
Last updated July 18, 2000
Table 1. ftsZ is universally present in all bacteria
(except three), but all the other Fts proteins are absent from
several or most species.
Species names: Ec: Escherichia coli; Aac:
Actinobacillus actinomycetemcomitans; Hi: Hemophilus
influenzae; Ng: Neisseria meningitidis; Xf: Xylella
fastidiosus; Vc: Vibrio cholorae; Yp: Yersinia pesti;s
Bs: Bacillus subtilis; Bb: Borelia burgdorferii;
Dr: Dynococcus radiodurans; Hp: Helicobacter pylori;
Mtb: Mycobacterium tuberculosis; Rp: Rickettsia
prowazekii; Sp: Streptococcus pyogenes; Sy:
Synechocystis Sp; Tp: Treponema pallidum; Aa:
Aquifex aeolicus; Tm: Thermotoga maritima; Ct:
Chlamydia trachomatis; Mg: Mycoplasma genitalium; Mpn:
Mycoplasma pneumoniae; Uu: Ureaplasma urealyticum;
Af: Archeoglobus flugidus; Ap: Aeropyrum pernix;
Mj: Methanococcus jannaschii; Mt: Methanobacterium
thermoautotrophicum; Ph: Pyrococcus horikoshii; Pa:
Pyrococcus abyssi.
Methods:The database of complete complete genomes was searched
at
http://www.ncbi.nlm.nih.gov/Microb_blast/unfinishedgenome.html
using E. coli amino acid sequences for all of the Fts genes (B.
subtilis for SMC) and the tblastn algorithm (Altschul, 1997). All
hits that look significant are indicated as a 1. Those near the
bottom of the Blast list, significantly below the others, are
indicated with 1? to indicate a probable homolog, but questionable.
0? indicates even weaker hits, ones that don't seem
meaningful.
*Footnotes:
1. FtsQ has a functional analogdivIB in B.
subtilis , which has only very weak sequence homology to
ftsQ. divIB genes are found in several gram positive
bacteria.
2. The B. subtilis homolog of E. coli ftsK is called
spoIIIE. Several of the ftsK genes are shorter than the
E. coli gene and match only the second half. Several bacteria
have additional proteins with weaker homology to ftsK, and we
have not made an exhaustive attempt to classify these.
3. A number of species have genes with weak homology to E. coli
minD, and have been classified separately as S0g, ParA and
ParB.
4. SMCs are a family of proteins involved in DNA condensation. Some gram negative bacteria have a MukB protein, which is distantly related to SMC's but probably a functional homolog. Several other distantly related proteins such as E. coli SbcC, are not included. See Melby et al.1999 (J. Cell Biol. 142:1595) for a detailed discussion of the SMC/MukB family.
See Erickson, H.P.
"Dynamin and FtsZ: missing links in mitochondrial and bacterial
division."
J. Cell Biol. 148:1103. for discussion of FtsZ in mitochondria and
chloroplasts, and for the
three bacteria with no FtsZ.