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Duke
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Duke
Medical Center
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| Scott
Soderling,
Ph.D.
(Pharmacology,
University of Washington)
Assistant
Professor, Cell Biology
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Signaling
through the Rho family of small GTPases plays a critical
role in the regulation of actin dynamics in neurons.
By experimentally manipulating the activities of
the Rho GTPases it is now clear that they regulate
many key aspects neuronal function, including axonal
guidance, dendritic arbor growth, and spine morphogenesis
and plasticity. Alterations
in Rho family signaling pathways are also thought
to underlie several neurological disorders, including
forms of mental retardation and epilepsy. Recent
work has identified many of the signaling proteins
that are implicated in these processes, but the molecular
logic of how these pathways are integrated is largely
fragmented.
We
now know that efficient signal transduction relies on
the organization of signaling pathways around multi-protein
complexes. Rho GTPase signaling depends on the balance
of the opposing activities of GEF and GAP proteins. How
these activities are organized is largely unknown,
yet understanding this is critical for determining
how signaling specificity is achieved and how Rho GTPase
signaling drives the cellular functions of neurons.
My
laboratory is interested in two broad questions. 1)
How is Rho-family GTPase signaling to the actin cytoskeleton
in neurons regulated by multi-protein complexes? 2)
How does the organization of these signaling pathways
translate to the regulation of normal neuronal function?
To answer these
questions our laboratory utilizes a combination of
biochemistry, molecular biology, cellular imaging and
mouse genetics. |
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| Email
S.Soderling@cellbio.duke.edu
318 Nanaline Duke Building, Box 3709
Duke University Medical Center
Durham, NC 27710
Telephone (919)
684-9001
Fax (919)
684-5481
Soderling
Lab Website |
Selected
Recent Publications
Soderling, S. H., Guire, E. S., Kaech, S., White, J., Zhang,
F., Schutz, K., Langeberg, L. K., Banker, G., Raber, J.,
Scott, J. D. (2007). A WAVE-1 and WRP signaling complex
regulates spine density, synaptic plasticity, and memory.
J Neurosci, 27(2):355-65. -PDF-
Soderling
S.H., Scott J.D. (2006). WAVE Signalling: From Biochemistry
to Biology.
Biochem Soc Trans. Feb 34(Pt 1); 73-76. -PDF-
Alto, N.M., Soderling, S.H., Hoshi, N., and Scott, J.D.,
(2003). Bioinformatic Design of AKAP in silica, a Highly
Potent PKA Anchoring Inhibitor Peptide. Proc Natl Acad
Sci U S A, 100(8):4445-50. -PDF-
Soderling, S.H., Langeberg, L.K., Soderling, J.A., Davee, S.M., Simerly, R.,
Raber, J. and John D. Scott and Scott, J.D., (2003). Loss of WAVE-1 Causes Sensorimotor
Retardation and Reduced Learning and Memory in Mice. Proc Natl Acad Sci U S
A, 100, 1723-1728. -PDF-
Soderling, S. H., Binns, K.L, Wayman, G.A, Davee, S.M.,
Ong, S.H., Pawson, T., and Scott, J.D., (2002). WRP, a
Novel Component of the WAVE-1 Complex that Attenuates Rac
Mediated Signaling. Nat. Cell Bio., Dec;4(12):970-5. -PDF-
Westphal, R. S., Soderling, S. H., Alto, N. M., Langeberg, L. K., and Scott,
J. D. (2000). Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an
actin- associated multi-kinase scaffold. Embo J 19, 4589-600. -PDF-
Soderling, S. H., Bayuga, S. J., and Beavo, J. A. (1999). Isolation and characterization
of a dual-substrate phosphodiesterase gene family: PDE10A. Proc Natl Acad Sci
U S A 96, 7071-6. -PDF-
Soderling, S. H., Bayuga, S. J., and Beavo, J. A. (1998). Cloning and characterization
of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc Natl Acad Sci U
S A 95, 8991-6. -PDF-
Soderling, S. H., Bayuga, S. J., and Beavo, J. A. (1998). Identification and
characterization of a novel family of cyclic nucleotide phosphodiesterases. J
Biol Chem 273, 15553-8. -PDF-
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